Launch vehicle wind and turbulence response by nonstationary statistical methods

Nonstationary adjoint algorithm for determining launch vehicle flight loads due to winds and turbulenc

Uncertainty Relations for Positive Operator Valued Measures

How much unavoidable randomness is generated by a Positive Operator Valued Measure (POVM)? We address this question using two complementary approaches. First we study the variance of a real variable associated to the POVM outcomes. In this context we introduce an uncertainty operator which measures how much additional noise is introduced by carrying out a POVM rather than a von Neumann measurement. We illustrate this first approach by studying the variances of joint estimates of \sigma_x and \sigma_z for spin 1/2 particles. We show that for unbiased measurements the sum of these variances is lower bounded by 1. In our second approach we study the entropy of the POVM outcomes. In particular we try to establish lower bounds on the entropy of the POVM outcomes. We illustrate this second approach by examples.Comment: 5 pages, minor modifications and clarification

The Role of Kinetic Energy Flux in the Convective Urca Process

The previous analysis of the convective Urca neutrino loss process in degenerate, convective, quasi-static, carbon-burning cores by Barkat and Wheeler omitted specific consideration of the role of the kinetic energy flux. The arguments of Barkat and Wheeler that steady-state composition gradients exist are correct, but chemical equilibrium does not result in net cooling. Barkat and Wheeler included a "work" term that effectively removed energy from the total energy budget that could only have come from the kinetic energy, which must remain positive. Consideration of the kinetic energy in the thermodynamics of the convective Urca process shows that the convective Urca neutrinos reduce the rate of increase of entropy that would otherwise be associated with the input of nuclear energy and slow down the convective current, but, unlike the "thermal" Urca process do not reduce the entropy or temperature.Comment: 16 pages, AAS LaTex, in press, Astrophysical Journal, September 20, Vol 52

Maiden Castle, Dorset

This is an account of the archaeological excavations of Maiden Castle, in Dorset, England. Included are descriptions of artefacts such as pottery and human remains, together with an account of the methodology used to unearth these

Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts

© 2019 Published by Elsevier Inc.Arterial medial calcification (AMC) is the deposition of calcium phosphate mineral, often as hydroxyapatite, inthe medial layer of the arteries. AMC shares some similarities to skeletal mineralisation and has been associatedwith the transdifferentiation of vascular smooth muscle cells (VSMCs) towards an osteoblast-like phenotype. Thisstudy used primary mouse VSMCs and calvarial osteoblasts to directly compare the established and widely usedin vitromodels of AMC and bone formation. Significant differences were identified between osteoblasts andcalcifying VSMCs. First, osteoblasts formed large mineralised bone nodules that were associated with widespreaddeposition of an extracellular collagenous matrix. In contrast, VSMCs formed small discrete regions of calcifi-cation that were not associated with collagen deposition and did not resemble bone. Second, calcifying VSMCsdisplayed a progressive reduction in cell viability over time (≤7-fold), with a 50% increase in apoptosis,whereas osteoblast and control VSMCs viability remained unchanged. Third, osteoblasts expressed high levels ofalkaline phosphatase (TNAP) activity and TNAP inhibition reduced bone formation by to 90%. TNAP activity incalcifying VSMCs was∼100-fold lower than that of bone-forming osteoblasts and cultures treated withβ-gly-cerophosphate, a TNAP substrate, did not calcify. Furthermore, TNAP inhibition had no effect on VSMC calci-fication. Although, VSMC calcification was associated with increased mRNA expression of osteoblast-relatedgenes (e.g. Runx2, osterix, osteocalcin, osteopontin), the relative expression of these genes was up to 40-foldlower in calcifying VSMCs versus bone-forming osteoblasts. In summary, calcifying VSMCsin vitrodisplay somelimited osteoblast-like characteristics but also differ in several key respects: 1) their inability to form collagen-containing bone; 2) their lack of reliance on TNAP to promote mineral deposition; and, 3) the deleterious effectof calcification on their viability.Peer reviewedFinal Published versio

Ultrastructural Characteristics of Mature Wood of Southern Red Oak (Quercus Falcata Michx.) and White Oak (Quercus Alba L.)

The fine structure of mature wood of white oak and southern red oak was studied using ultrathin sections and direct carbon replicas. In most details, the fine structure of the wood of these two species is similar. Differences detected include a slightly coarser appearance of intertracheary pit membranes and fewer vessel-ray parenchyma pit contacts in southern red oak. Intervessel pitting was not found in either species, implying that flow between vessels occurs via vasicentric tracheids as vessel-vasi-centric tracheid and vasicentric tracheid-vasicentric tracheid pitting is abundant. The appearance of the pit membranes differs in pits interconnecting different types of cells, e.g. vessel-vasicentric tracheid pit membranes were thicker than vasicentric tracheid-vasicentric tracheid pit membranes. Differences in the orientation of the pit aperture in the bordered pits of various cell types appeared to correlate with differing S2 orientations. Vessel-vasicentric tracheid and vasicentric tracheid-vasicentric tracheid pit membranes in the outer conducting sapwood and inner nonconducting sapwood appeared similar with randomly arranged microfibrils and no visible openings. In the outer and inner heartwood, these membranes were coated and infiltrated by extractives. The low permeability of multiseriate rays compared with uniseriate rays may be accounted for by the scarcity of lateral wall pitting and direct vessel-ray parenchyma cell contact in the interior of the multiseriate ray

Gravitational Geons Revisited

A careful analysis of the gravitational geon solution found by Brill and Hartle is made. The gravitational wave expansion they used is shown to be consistent and to result in a gauge invariant wave equation. It also results in a gauge invariant effective stress-energy tensor for the gravitational waves provided that a generalized definition of a gauge transformation is used. To leading order this gauge transformation is the same as the usual one for gravitational waves. It is shown that the geon solution is a self-consistent solution to Einstein's equations and that, to leading order, the equations describing the geometry of the gravitational geon are identical to those derived by Wheeler for the electromagnetic geon. An appendix provides an existence proof for geon solutions to these equations.Comment: 18 pages, ReVTeX. To appear in Physical Review D. Significant changes include more details in the derivations of certain key equations and the addition of an appendix containing a proof of the existence of a geon solution to the equations derived by Wheeler. Also a reference has been added and various minor changes have been mad

Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury

Chronic kidney disease (CKD) is a common medical condition of ageing cats. In most cases the underlying aetiology is unknown, but the most frequently reported pathological diagnosis is renal tubulointerstitial fibrosis. Renal fibrosis, characterised by extensive accumulation of extra-cellular matrix within the interstitium, is thought to be the final common pathway for all kidney diseases and is the pathological lesion best correlated with function in both humans and cats. As a convergent pathway, renal fibrosis provides an ideal target for the treatment of CKD and knowledge of the underlying fibrotic process is essential for the future development of novel therapies. There are many mediators and mechanisms of renal fibrosis reported in the literature, of which only a few have been investigated in the cat. This article reviews the process of renal fibrosis and discusses the most commonly cited mediators and mechanisms of progressive renal injury, with particular focus on the potential significance to feline CKD

Corticosterone Acts in the Nucleus Accumbens to Enhance Dopamine Signaling and Potentiate Reinstatement of Cocaine Seeking

Stressful life events are important contributors to relapse in recovering cocaine addicts, but the mechanisms by which they influence motivational systems are poorly understood. Studies suggest that stress may “set the stage” for relapse by increasing the sensitivity of brain reward circuits to drug-associated stimuli. We examined the effects of stress and corticosterone on behavioral and neurochemical responses of rats to a cocaine prime after cocaine self-administration and extinction. Exposure of rats to acute electric footshock stress did not by itself reinstate drug-seeking behavior but potentiated reinstatement in response to a subthreshold dose of cocaine. This effect of stress was not observed in adrenalectomized animals, and was reproduced in nonstressed animals by administration of corticosterone at a dose that reproduced stress-induced plasma levels. Pretreatment with the glucocorticoid receptor antagonist RU38486 did not block the corticosterone effect. Corticosterone potentiated cocaine-induced increases in extracellular dopamine in the nucleus accumbens (NAc), and pharmacological blockade of NAc dopamine receptors blocked corticosterone-induced potentiation of reinstatement. Intra-accumbens administration of corticosterone reproduced the behavioral effects of stress and systemic corticosterone. Corticosterone treatment acutely decreased NAc dopamine clearance measured by fast-scan cyclic voltammetry, suggesting that inhibition of uptake2-mediated dopamine clearance may underlie corticosterone effects. Consistent with this hypothesis, intra-accumbens administration of the uptake2 inhibitor normetanephrine potentiated cocaine-induced reinstatement. Expression of organic cation transporter 3, a corticosterone-sensitive uptake2 transporter, was detected on NAc neurons. These findings reveal a novel mechanism by which stress hormones can rapidly regulate dopamine signaling and contribute to the impact of stress on drug intake

The Convective Urca Process with Implicit Two-Dimensional Hydrodynamics

Consideration of the role of the convective flux in the thermodymics of the convective Urca neutrino loss process in degenerate, convective, quasi-static, carbon-burning cores shows that the convective Urca process slows down the convective current around the Urca-shell, but, unlike the "thermal" Urca process, does not reduce the entropy or temperature for a given convective volume. Here we demonstrate these effects with two-dimensional numerical hydrodynamical calculations. These two-dimensional implicit hydrodynamics calculations invoke an artificial speeding up of the nuclear and weak rates. They should thus be regarded as indicative, but still qualitative. We find that, compared to a case with no Urca-active nuclei, the case with Urca effects leads to a higher entropy in the convective core because the energy released by nuclear burning is confined to a smaller volume by the effective boundary at the Urca shell. All else being equal, this will tend to accelerate the progression to dynamical runaway. We discuss the open issues regarding the impact of the convective Urca process on the evolution to the "smoldering phase" and then to dynamical runaway.Comment: 22 pages, 11 figures, accepted for publication in the Astrophysical Journa